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 7fc4
X-WR-CALNAME:DIAS Nobel Colloquium: Stefan Hell\, Max Planck Institute for
  Multidisciplinary Sciences\, Göttingen & Max Planck Institute for Medica
 l Research\, Heidelberg
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DESCRIPTION:[b] MINFLUX nanoscopy and related matters [/b] [nl] [nl] \n\nW
 e are looking forward to welcoming Stefan Hell\, director at both the Max
  Planck Institute for Multidisciplinary Sciences in Göttingen and the Max
  Planck Institute for Medical Research in Heidelberg\, Germany\, at the D
 anish Institute for Advanced Study.\n[nl] [nl]\n\nIn 2014 he received the
  Nobel Prize in Chemistry for the development of super-resolved fluoresce
 nce microscopy.\n[nl] [nl]\n\nIn this talk\, he will show how an in-depth
  description of the basic principles of diffraction-unlimited fluorescenc
 e microscopy (nanoscopy) has spawned a new powerful superresolution conce
 pt\, namely MINFLUX nanoscopy. MINFLUX utilizes a local excitation intens
 ity minimum (of a doughnut or a standing wave) that is targeted like a pr
 obe in order to localize the fluorescent molecule to be registered. \n[nl
 ] [nl] \nIn combination with single-molecule switching for sequential reg
 istration\, MINFLUX has obtained the ultimate (super)resolution: the size
  of a molecule. MINFLUX nanoscopy\, providing 1–3 nanometer resolution in
  fixed and living cells\, is presently being established for routine fluo
 rescence imaging at the highest\, molecular-size resolution levels. \n[nl
 ] [nl] \nRelying on fewer detected photons than popular camera-based loca
 lization\, MINFLUX and related MINSTED nanoscopies are poised to open a n
 ew chapter in the imaging of protein complexes and distributions in fixed
  and living cells. MINFLUX is also set to transform the single-molecule a
 nalysis of dynamic processes\, as already demonstrated by tracking in det
 ail the unhindered stepping of the motor protein kinesin-1 on microtubule
 s at up to physiological ATP concentrations\, and providing answers to lo
 ngstanding questions with respect to the kinesin-1 mechanochemical cycle.
 \n\n[nl][nl] \n\n[b] About: [/b] [nl] \nStefan Hell is credited with havi
 ng conceived\, validated and applied the first viable concept for overcom
 ing Abbe’s diffraction-limited resolution barrier in a light-focusing flu
 orescence microscope. For this accomplishment he has received numerous aw
 ards\, including the 2014 Kavli Prize in Nanoscience and the Nobel Prize 
 in Chemistry.\n[nl] [nl]\nHe received his doctorate (1990) in physics fro
 m the University of Heidelberg. From 1991 to 1993 he worked at the Europe
 an Molecular Biology Laboratory\, followed by stays as a senior researche
 r at the University of Turku\, Finland\, between 1993 and 1996\, and as a
  visiting scientist at the University of Oxford\, England\, in 1994. In 1
 997 he was appointed to the MPI for Biophysical Chemistry (named Max Plan
 ck Institute for Multidisciplinary Sciences since 2022) in Göttingen as a
  group leader\, and was promoted to director in 2002. From 2003 to 2017 h
 e also led a research group at the German Cancer Research Center (DKFZ). 
 Hell holds honorary professorships in physics at the Universities of Heid
 elberg and Göttingen.\n \n\n[nl][nl] \nRead more about Stefan W. Hell [ur
 l=https://www.mr.mpg.de/14184202/hellcv]here[/url] and [url=https://www.n
 obelprize.org/prizes/chemistry/2014/hell/facts/]here[/url]\n\n[nl] [nl]\n
 Read more about Stefan Hell Labs [url=https://nanobiophotonics.mpibpc.mpg
 .de/]here[/url]\n[nl] [nl]\n\n\n\nThe lecture takes place in the DIAS Aud
 itorium\, Fioniavej 34. Everybody is welcome and no registration is neede
 d. \n\n[nl][nl] \n\n[i] Live stream it at [url=https://youtube.com/@danis
 hias]youtube.com/@danish-ias[/url]  [/i] \n[nl] [nl]
DTEND:20230510T101500Z
DTSTAMP:20260420T092855Z
DTSTART:20230510T091500Z
LOCATION:DIAS\, Fioniavej 34\, 5230\, Odense M
SEQUENCE:0
SUMMARY:DIAS Nobel Colloquium: Stefan Hell\, Max Planck Institute for Mult
 idisciplinary Sciences\, Göttingen & Max Planck Institute for Medical Res
 earch\, Heidelberg
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